<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Schlapbach LJ</dc:creator>
  <dc:creator>Aebi C</dc:creator>
  <dc:creator>Fisch U</dc:creator>
  <dc:creator>Ammann RA</dc:creator>
  <dc:creator>Otth M</dc:creator>
  <dc:creator>Bigler S</dc:creator>
  <dc:creator>Nelle M</dc:creator>
  <dc:creator>Berger S</dc:creator>
  <dc:creator>Kessler U</dc:creator>
  <dc:date>2008</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Necrotising enterocolitis (NEC) causes significant morbidity and mortality in premature infants. The role of innate immunity in the pathogenesis of NEC remains unclear. Mannose-binding lectin (MBL) recognizes microorganisms and activates the complement system via MBL-associated serine protease-2 (MASP-2). The aim of this study was to investigate whether MBL and MASP-2 are associated with NEC. This observational case-control study included 32 infants with radiologically confirmed NEC and 64 controls. MBL and MASP-2 were measured in cord blood using ELISA. Multivariate logistic regression was performed. Of the 32 NEC cases (median gestational age, 30.5 wk), 13 (41%) were operated and 5 (16%) died. MASP-2 cord blood concentration ranged from undetectable (&lt;10 ng/mL) to 277 ng/mL. Eighteen of 32 (56%) NEC cases had higher MASP-2 levels (&gt; or =30 ng/mL) compared with 22 of 64 (34%) controls (univariate OR 2.46; 95% CI 1.03-5.85; p = 0.043). Higher cord blood MASP-2 levels were significantly associated with an increased risk of NEC in multivariate analysis (OR 3.00; 95% CI 1.17-7.93; p = 0.027). MBL levels were not associated with NEC (p = 0.64). In conclusion, infants later developing NEC had significantly higher MASP-2 cord blood levels compared with controls. Higher MASP-2 may favor complement-mediated inflammation and could thereby predispose to NEC.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/1057</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1203/PDR.0b013e3181841335</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/18596574</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Pediatric research. - 2008</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Case-Control Studies</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Complement Activation</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Enterocolitis, Necrotizing</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Fetal Blood</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Gestational Age</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Infant</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Infant, Newborn</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Mannose-Binding Lectin</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Mannose-Binding Protein-Associated Serine Proteases</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Radiography</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Risk Factors</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Up-Regulation</dc:subject>
  <dc:title xmlns:ns14="xml" ns14:lang="en">Higher cord blood levels of mannose-binding lectin-associated serine protease-2 in infants with necrotising enterocolitis.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>