Menni C Kiddle SJ Mangino M Viñuela A Psatha M Steves C Sattlecker M Buil A Newhouse S Nelson S Williams S Voyle N Soininen H Kloszewska I Mecocci P Tsolaki M Vellas B Lovestone S Spector TD Dobson R Valdes AM 2015 To elucidate the proteomic features of aging in plasma, the subproteome targeted by the SOMAscan assay was profiled in blood samples from 202 females from the TwinsUK cohort. Findings were replicated in 677 independent individuals from the AddNeuroMed, Alzheimer's Research UK, and Dementia Case Registry cohorts. Results were further validated using RNAseq data from whole blood in TwinsUK and the most significant proteins were tested for association with aging-related phenotypes after adjustment for age. Eleven proteins were associated with chronological age and were replicated at protein level in an independent population. These were further investigated at gene expression level in 384 females from the TwinsUK cohort. The two most strongly associated proteins were chordin-like protein 1 (meta-analysis β [SE] = 0.013 [0.001], p = 3.66 × 10(-46)) and pleiotrophin (0.012 [0.005], p = 3.88 × 10(-41)). Chordin-like protein 1 was also significantly correlated with birthweight (0.06 [0.02], p = 0.005) and with the individual Framingham 10-years cardiovascular risk scores in TwinsUK (0.71 [0.18], p = 9.9 × 10(-5)). Pleiotrophin is a secreted growth factor with a plethora of functions in multiple tissues and known to be a marker for cardiovascular risk and osteoporosis. Our study highlights the importance of proteomics to identify some molecular mechanisms involved in human health and aging. application/pdf https://sonar.ch/global/documents/109338 eng info:eu-repo/semantics/altIdentifier/doi/10.1093/gerona/glu121 info:eu-repo/semantics/altIdentifier/pmid/25123647 info:eu-repo/semantics/openAccess The journals of gerontology. Series A, Biological sciences and medical sciences. - 2015 Aging Aptamers. Blood biomarkers Early development Nucleotide Proteomics Adult Aged Aged, 80 and over Aging Biomarkers Carrier Proteins Cohort Studies Cytokines Eye Proteins Female Humans Insulin-Like Growth Factor Binding Protein 6 Male Matrix Metalloproteinase 12 Middle Aged Nerve Tissue Proteins Phenotype Proteomics Registries Twins United Kingdom Circulating Proteomic Signatures of Chronological Age. http://purl.org/coar/resource_type/c_6501