<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Mariani L</dc:creator>
  <dc:creator>Deiana G</dc:creator>
  <dc:creator>Vassella E</dc:creator>
  <dc:creator>Fathi AR</dc:creator>
  <dc:creator>Murtin C</dc:creator>
  <dc:creator>Arnold M</dc:creator>
  <dc:creator>Vajtai I</dc:creator>
  <dc:creator>Weis J</dc:creator>
  <dc:creator>Siegenthaler P</dc:creator>
  <dc:creator>Schobesberger M</dc:creator>
  <dc:creator>Reinert MM</dc:creator>
  <dc:date>2006</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">PURPOSE
This study was conducted to elucidate the impact of loss of heterozygosity (LOH) for chromosomes 1p36 and 19q13 on the overall survival of patients with diffusely infiltrating WHO grade 2 gliomas treated without chemotherapy.


PATIENTS AND METHODS
We assessed the LOH status of tumors from patients harboring WHO grade 2 gliomas diagnosed between 1991 and 2000. Patients were either followed after initial biopsy or treated by surgery and/or radiation therapy (RT). Overall survival, time to malignant transformation, and progression-free survival were last updated as of March 2005.


RESULTS
Of a total of 79 patients, LOH 1p36 and LOH 19q13 could be assessed in 67 and 66 patients, respectively. The median follow-up after diagnosis was 6 years. Loss of either 1p or 19q, in particular codeletion(s) at both loci, was found to positively impact on both overall survival (log-rank P &lt; .01), progression-free survival, and survival without malignant transformation (P &lt; .05). Tumor volume (P &lt; .0001), neurologic deficits at diagnosis (P &lt; .01), involvement of more than one lobe (P &lt; .01), and absence of an oligodendroglial component (P &lt; .05) were also predictors of shorter overall survival. The extent of surgery was similar in patients with or without LOH 1p and/or 19q; RT was more frequently resorted to for patients without than for patients with LOH 1p/19q (30% v 60%).


CONCLUSION
The presence of LOH on either 1p36 or 19q13, and in particular codeletion of both loci is a strong, nontreatment-related, prognostic factor for overall survival in patients with diffusely infiltrating WHO grade 2 gliomas.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/1172</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1200/JCO.2006.05.9238</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/16966689</dc:relation>
  <dc:source>Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 2006</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Adult</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Aged</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Brain Neoplasms</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Chromosomes, Human, Pair 1</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Chromosomes, Human, Pair 19</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Female</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Follow-Up Studies</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Glioma</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Loss of Heterozygosity</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Male</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Middle Aged</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Prognosis</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Survival Analysis</dc:subject>
  <dc:title xmlns:ns15="xml" ns15:lang="en">Loss of heterozygosity 1p36 and 19q13 is a prognostic factor for overall survival in patients with diffuse WHO grade 2 gliomas treated without chemotherapy.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>