Puntschart, A. Wey, E. Jostarndt, K. Vogt, M. Wittwer, M. Widmer, H. R. Hoppeler, H. Billeter, R. <jats:p> It is believed that the induction of the fos and jun gene family of transcription factors might be at the origin of genetic events leading to the differential regulation of muscle-specific genes. We have investigated the effect of a 30-min running bout in untrained subjects on the expression of the mRNAs of all members of the fos and jun gene families, including c- fos, fosB, fosBdel, fra-1, and fra-2 as well as c- jun, junB, and junD. While the fos family members were transiently upregulated 10- to 20-fold (an exception being fra-2), the induction of the jun family members was up to 3-fold only. The induction of c- fos could also be demonstrated at the protein level. Both c- fos and c- jun mRNAs were coinduced in muscle fiber nuclei. The induction was not restricted to a particular fiber type, as expected from established muscle fiber recruitment schemes, but followed a “patchy” pattern confined to certain regions of the muscle. The signals leading to the expression of these immediate early genes are therefore unclear. </jats:p> https://sonar.ch/global/documents/119575 eng info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpcell.1998.274.1.c129 info:eu-repo/semantics/altIdentifier/issn/0363-6143 American Journal of Physiology-Cell Physiology. - American Physiological Society. - 1998, vol. 274, no. 1, p. C129-C137 Cell Biology Physiology Expression of fos andjun genes in human skeletal muscle after exercise http://purl.org/coar/resource_type/c_6501