Porta F Bracht H Weikert C Beck M Takala J Brandt S Hiltebrand LB Jakob SM 2009 Catecholamines are frequently used in sepsis, but their interaction with mitochondrial function is controversial. We incubated isolated native and endotoxin-exposed swine liver mitochondria with either dopamine, dobutamine, noradrenaline or placebo for 1 h. Mitochondrial State 3 and 4 respiration and their ratio (RCR) were determined for respiratory chain complexes I, II and IV. All catecholamines impaired glutamate-dependent RCR (p = 0.046), predominantly in native mitochondria. Endotoxin incubation alone induced a decrease in glutamate-dependent RCR compared to control samples (p = 0.002). We conclude that catecholamines and endotoxin impair the efficiency of mitochondrial complex I respiration in vitro. application/pdf https://sonar.ch/global/documents/1196 eng info:eu-repo/semantics/altIdentifier/doi/10.1007/s10753-009-9138-y info:eu-repo/semantics/altIdentifier/pmid/19603262 info:eu-repo/semantics/openAccess Inflammation. - 2009 Adenosine Diphosphate Adenosine Triphosphate Animals Catecholamines Cell Respiration Endotoxins Mitochondria, Liver Oxygen Consumption Swine Time Factors Effects of endotoxin and catecholamines on hepatic mitochondrial respiration. http://purl.org/coar/resource_type/c_6501