<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Theoulakis P</dc:creator>
  <dc:creator>Goldblum D</dc:creator>
  <dc:creator>Zimmerli S</dc:creator>
  <dc:creator>Muehlethaler K</dc:creator>
  <dc:creator>Frueh BE</dc:creator>
  <dc:date>2009</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">PURPOSE
The purpose of this study was to report the first case of fungal keratitis resulting from Thielavia sp.


METHODS
We conducted a retrospective chart review.


RESULTS
A 10-year old girl presented 2 weeks after ocular plant injury with pain and corneal stromal infiltration with central ulceration and ill-defined margins. Cultures of corneal scrapings and biopsy sequence analysis of the ribosomal internal transcribed spacer region isolated Thielavia subthermophila Mouchacca. Clinically, the organism appeared to respond to topical amphotericin B and oral voriconazole. Best-corrected visual acuity at last follow-up visit counted 0.5.


CONCLUSIONS
A rare case of Thielavia sp. keratitis was successfully treated with topical amphotericin B and oral voriconazole. Newly developed molecular diagnostic tools contribute to the recognition of a widening spectrum of emerging fungal pathogens capable of causing serious ocular infections.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/1222</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1097/ICO.0b013e31819717f4</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/19724200</dc:relation>
  <dc:source>Cornea. - 2009</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Amphotericin B</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Antifungal Agents</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Child</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Corneal Ulcer</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Drug Therapy, Combination</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Eye Infections, Fungal</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Female</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Mycoses</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Pyrimidines</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Retrospective Studies</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Sordariales</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Triazoles</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Voriconazole</dc:subject>
  <dc:title xmlns:ns15="xml" ns15:lang="en">Keratitis resulting from Thielavia subthermophila Mouchacca.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>