Vasella A Davies GJ Böhm M 2002 The three-dimensional structure of glycosidases and of their complexes and the study of transition-state mimics reveal structural details that correlate with mechanism. Of particular interest are the transition-state conformations harnessed by individual enzymes and the substrate distortion observed in enzyme-ligand complexes. 3D-structure in synergy with transition-state mimicry opens the way for mechanistic interpretation of enzyme inhibition and for the development of therapeutic agents. https://sonar.ch/global/documents/123440 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/s1367-5931(02)00380-0 info:eu-repo/semantics/altIdentifier/pmid/12413546 Current opinion in chemical biology. - 2002 Catalysis Enzyme Inhibitors Glycoside Hydrolases Hydrolysis Ligands Molecular Structure Mutagenesis Protein Conformation Stereoisomerism Substrate Specificity Glycosidase mechanisms. http://purl.org/coar/resource_type/c_6501