Jouffe C Cretenet G Symul L Martin E Atger F Naef F Gachon F 2013 Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of transcription regulators. Here we show that the circadian clock exerts its function also through the regulation of mRNA translation. Namely, the circadian clock influences the temporal translation of a subset of mRNAs involved in ribosome biogenesis by controlling the transcription of translation initiation factors as well as the clock-dependent rhythmic activation of signaling pathways involved in their regulation. Moreover, the circadian oscillator directly regulates the transcription of ribosomal protein mRNAs and ribosomal RNAs. Thus the circadian clock exerts a major role in coordinating transcription and translation steps underlying ribosome biogenesis. application/pdf https://sonar.ch/global/documents/126102 eng info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pbio.1001455 info:eu-repo/semantics/altIdentifier/pmid/23300384 info:eu-repo/semantics/openAccess PLoS biology. - 2013 ARNTL Transcription Factors Animals Circadian Clocks Circadian Rhythm Cryptochromes Enzyme Activation Eukaryotic Initiation Factors Extracellular Signal-Regulated MAP Kinases Gene Expression Regulation Mechanistic Target of Rapamycin Complex 1 Mice Mice, Inbred C57BL Mice, Knockout Multiprotein Complexes Pol1 Transcription Initiation Complex Proteins Protein Biosynthesis Proto-Oncogene Proteins c-akt RNA, Messenger RNA, Ribosomal Ribosomes Signal Transduction TOR Serine-Threonine Kinases The circadian clock coordinates ribosome biogenesis. http://purl.org/coar/resource_type/c_6501