Münz C 2011 Macroautophagy is a catabolic pathway in eukaryotic cells that has recently been shown to facilitate pathogen detection, pathogen restriction and pathogen-derived antigen presentation to CD4(+) T cells. Due to these protective functions during immune responses, several pathogens, including RNA and DNA viruses, have developed strategies to inhibit autophagosome generation or maturation. Interestingly, most of the respective viral proteins exert these functions via binding to Beclin-1, an essential macroautophagy protein that constitutes part of the phosphatidylinositol-3 kinase complexes that mark membranes for autophagosome generation and facilitate autophagosome fusion with lyososomes. The viruses that inhibit macroautophagy by this pathway include herpesviruses, HIV and influenza A virus. Inhibition either before or after autophagosome formation seems to benefit their viral replication by different mechanisms, which are discussed here. application/pdf https://sonar.ch/global/documents/12623 eng info:eu-repo/semantics/altIdentifier/doi/10.3390/v3071166 info:eu-repo/semantics/altIdentifier/pmid/21994775 info:eu-repo/semantics/openAccess Viruses. - 2011 HIV HSV KSHV autophagy immune evasion immunity influenza virus Animals Apoptosis Regulatory Proteins Autophagy Beclin-1 DNA Viruses Humans Immune Evasion Membrane Proteins RNA Viruses Virus Diseases Beclin-1 targeting for viral immune escape. http://purl.org/coar/resource_type/c_6501