<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Sellin ME</dc:creator>
  <dc:creator>Maslowski KM</dc:creator>
  <dc:creator>Maloy KJ</dc:creator>
  <dc:creator>Hardt WD</dc:creator>
  <dc:date>2015</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">While the functional importance of inflammasomes in blood-derived cell types is well established, it remains poorly understood how inflammasomes in nonhematopoietic cells contribute to mucosal immunity. Recent studies have revealed functional roles of inflammasomes - particularly NAIP/NLRC4, NLRP6, and noncanonical caspase-4 (caspase-11) - within epithelial cells of the gut in mucosal immune defense, inflammation, and tumorigenesis. Here, we review and discuss these findings in the broader context of tissue compartment-specific mucosal immunity. We propose several models whereby activities of the intestinal epithelial inflammasomes converge on mechanisms to remove compromised epithelial cells, maintain host-microbiota mutualism, and communicate with immune cells of the underlying lamina propria.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/127119</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.it.2015.06.002</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/26166583</dc:relation>
  <dc:source>Trends in immunology. - 2015</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">NLRP3</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">caspase-1</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">extrusion</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">innate immunity</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">intestinal epithelial cell (IEC)</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">mucus</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Immunity, Mucosal</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Inflammasomes</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Intestinal Mucosa</dc:subject>
  <dc:title xmlns:ns12="xml" ns12:lang="en">Inflammasomes of the intestinal epithelium.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>