<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Chellat MF</dc:creator>
  <dc:creator>Raguž L</dc:creator>
  <dc:creator>Riedl R</dc:creator>
  <dc:date>2016</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health. The past decades have seen a dramatic worldwide increase in human-pathogenic bacteria that are resistant to one or multiple antibiotics. More and more infections caused by resistant microorganisms fail to respond to conventional treatment, and in some cases, even last-resort antibiotics have lost their power. In addition, industry pipelines for the development of novel antibiotics have run dry over the past decades. A recent world health day by the World Health Organization titled "Combat drug resistance: no action today means no cure tomorrow" triggered an increase in research activity, and several promising strategies have been developed to restore treatment options against infections by resistant bacterial pathogens.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/128944</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1002/anie.201506818</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/27000559</dc:relation>
  <dc:source>Angewandte Chemie (International ed. in English). - 2016</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">antibiotic resistance</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">antibiotics</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">drug design</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">medicinal chemistry</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">structure-activity relationships</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Anti-Bacterial Agents</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Bacteria</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Bacterial Proteins</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Drug Design</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Drug Resistance, Multiple, Bacterial</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Macrolides</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Molecular Dynamics Simulation</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Organophosphates</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Oxazoles</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Oxazolidinones</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Structure-Activity Relationship</dc:subject>
  <dc:title xmlns:ns17="xml" ns17:lang="en">Targeting Antibiotic Resistance.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>