<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Stalder L</dc:creator>
  <dc:creator>Mühlemann O</dc:creator>
  <dc:date>2008</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">To ensure the accuracy of gene expression, eukaryotes have evolved several surveillance mechanisms. One of the best-studied quality control mechanisms is nonsense-mediated mRNA decay (NMD), which recognizes and degrades transcripts harboring a premature translation-termination codon (PTC), thereby preventing the production of faulty proteins. NMD regulates approximately 10% of human mRNAs, and its physiological importance is manifested by the fact that approximately 30% of disease-associated mutations generate PTCs. Although different mechanisms of PTC recognition have been proposed for different species, recent studies in Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, plants and mammals suggest a conserved model. Here, we summarize the latest results and discuss an emerging model for NMD and its implications for the regulation of gene expression.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/131444</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tcb.2008.04.005</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/18524595</dc:relation>
  <dc:source>Trends in cell biology. - 2008</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Caenorhabditis elegans</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Drosophila melanogaster</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Evolution, Molecular</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Gene Expression Regulation</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Genetic Diseases, Inborn</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Models, Biological</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Mutation</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Protein Biosynthesis</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Protein Structure, Tertiary</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">RNA Processing, Post-Transcriptional</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">RNA Stability</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">RNA, Messenger</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Saccharomyces cerevisiae</dc:subject>
  <dc:title xmlns:ns16="xml" ns16:lang="en">The meaning of nonsense.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>