<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Wang D</dc:creator>
  <dc:creator>Huang J</dc:creator>
  <dc:creator>Gui T</dc:creator>
  <dc:creator>Yang Y</dc:creator>
  <dc:creator>Feng T</dc:creator>
  <dc:creator>Tzvetkov NT</dc:creator>
  <dc:creator>Xu T</dc:creator>
  <dc:creator>Gai Z</dc:creator>
  <dc:creator>Zhou Y</dc:creator>
  <dc:creator>Zhang J</dc:creator>
  <dc:creator>Atanasov AG</dc:creator>
  <dc:date>2020</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Scavenger receptor class B type I (SR-BI) protein is an integral membrane glycoprotein. SR-BI is emerging as a multifunctional protein, which regulates autophagy, efferocytosis, cell survival and inflammation. It is well known that SR-BI plays a critical role in lipoprotein metabolism by mediating cholesteryl esters selective uptake and the bi-directional flux of free cholesterol. Recently, SR-BI has also been identified as a potential marker for cancer diagnosis, prognosis, or even a treatment target. Natural products are a promising source for the discovery of new drug leads. Multiple natural products were identified to regulate SR-BI protein expression. There are still a number of challenges in modulating SR-BI expression in cancer and in using natural products for modulation of such protein expression. In this review, our purpose is to discuss the relationship between SR-BI protein and cancer, and the molecular mechanisms regulating SR-BI expression, as well as to provide an overview of natural products that regulate SR-BI expression.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/135084</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.semcancer.2019.12.025</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/31935456</dc:relation>
  <dc:source>Seminars in cancer biology. - 2020</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Cancer</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Molecular mechanisms</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Natural products</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Scavenger receptor class B type I</dc:subject>
  <dc:title xmlns:ns5="xml" ns5:lang="en">SR-BI as a target of natural products and its significance in cancer.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>