Feng ZY Louis J Kindler V Pedrazzini T Eliason JF Behin R Vassalli P 1988 Previous studies from our laboratory have shown that some in vitro maintained Leishmania major-specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin 3 (IL 3) and granulocyte-macrophage colony-stimulating factors after specific stimulation in vitro. In order to assess the involvement of such lymphokines in the exacerbation of cutaneous leishmaniasis by these L3T4+ T cells, the effect of the administration of important doses of IL 3 on the course of infection with L. major was investigated. The treatment of genetically susceptible BALB/c mice with IL 3 resulted in an enhancement of the size of lesions and favored the multiplication of parasites at anatomical sites distant from the primary lesion. Although IL 3 did not modify the development of lesions in genetically resistant CBA mice, this lymphokine promoted the growth of Leishmania in lymph node draining the lesion. Finally, the addition of IL 3 to macrophages parasitized in vitro enhanced the survival of intracellular Leishmania major. https://sonar.ch/global/documents/136024 eng info:eu-repo/semantics/altIdentifier/doi/10.1002/eji.1830180815 info:eu-repo/semantics/altIdentifier/pmid/2970970 European journal of immunology. - 1988 Animals Antigens, Differentiation, T-Lymphocyte Colony-Stimulating Factors Granulocyte-Macrophage Colony-Stimulating Factor Growth Substances Interleukin-3 Leishmania tropica Leishmaniasis Lymphocyte Activation Lymphocyte Culture Test, Mixed Macrophages Mice Mice, Inbred Strains T-Lymphocytes Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin 3. http://purl.org/coar/resource_type/c_6501