<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Ducrey B</dc:creator>
  <dc:creator>Marston A</dc:creator>
  <dc:creator>Göhring S</dc:creator>
  <dc:creator>Hartmann RW</dc:creator>
  <dc:creator>Hostettmann K</dc:creator>
  <dc:date>1997</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Species of the genus Epilobium (Onagraceae) have been investigated for their activity against 5 alpha-reductase and aromatase, two enzymes which are involved in the aetiology of benign prostatic hyperplasia (BPH). Activity-guided fractionation has led to the identification of two macrocyclic ellagitannins, oenothein A (1) and oenothein B (2), as the main constituents responsible for the inhibition of the two enzymes. Quantitation of oenothein B in 10 different species of Epilobium has shown that amounts of up to 14% in the crude plant extracts are possible.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/137059</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1055/s-2006-957624</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/9140222</dc:relation>
  <dc:source>Planta medica. - 1997</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">5-alpha Reductase Inhibitors</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Antineoplastic Agents, Phytogenic</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Aromatase Inhibitors</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Hydrolyzable Tannins</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Plants, Medicinal</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Tannins</dc:subject>
  <dc:title xmlns:ns7="xml" ns7:lang="en">Inhibition of 5 alpha-reductase and aromatase by the ellagitannins oenothein A and oenothein B from Epilobium species.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>
