<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Kulik EM</dc:creator>
  <dc:creator>Lenkeit K</dc:creator>
  <dc:creator>Chenaux S</dc:creator>
  <dc:creator>Meyer J</dc:creator>
  <dc:date>2008</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">OBJECTIVES
The aim of this study was to evaluate the resistance profiles of Aggregatibacter (Actinobacillus) actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia/Prevotella nigrescens and to detect possible changes in antibiotic resistance over the time period of 1991-2005.


METHODS
A. actinomycetemcomitans (125 strains), P. gingivalis (152 strains) and P. intermedia/P. nigrescens (326 strains) isolated during the years 1991-2005 were tested for their susceptibility to amoxicillin/clavulanic acid, clindamycin, metronidazole, phenoxymethylpenicillin and tetracycline using the Etest.


RESULTS
No antibiotic resistance was detected in P. gingivalis, whereas a few isolates of P. intermedia were not susceptible to clindamycin (0.9%), phenoxymethylpenicillin (13.5%) or tetracycline (12.6%). Amoxicillin/clavulanic acid, tetracycline and metronidazole were the most effective antibiotics against A. actinomycetemcomitans with 0%, 0.8% and 20.8% non-susceptible isolates, respectively. However, 88% of the A. actinomycetemcomitans isolates were non-susceptible to phenoxymethylpenicillin and 88% to clindamycin. When strains isolated in the years 1991-94 were compared with those isolated in the years 2001-04, there was no statistically significant difference in the percentage of A. actinomycetemcomitans strains non-susceptible to clindamycin, metronidazole or phenoxymethylpenicillin, or in the percentage of P. intermedia strains non-susceptible to phenoxymethylpenicillin or tetracycline (P &gt; 0.4 each).


CONCLUSIONS
Increasing antibiotic resistances in periodontopathogenic bacteria are not yet a problem in the Northern part of Switzerland.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/137625</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dkn079</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/18326855</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>The Journal of antimicrobial chemotherapy. - 2008</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Aggregatibacter actinomycetemcomitans</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Anti-Bacterial Agents</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Bacteroidaceae</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Drug Resistance, Multiple, Bacterial</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Microbial Sensitivity Tests</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Periodontal Diseases</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Time Factors</dc:subject>
  <dc:title xmlns:ns8="xml" ns8:lang="en">Antimicrobial susceptibility of periodontopathogenic bacteria.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>