Mullis PE 2007 When a child is not following the normal, predicted growth curve, an evaluation for underlying illness and central nervous system abnormalities is required and appropriate consideration should be given to genetic defects causing growth hormone (GH) deficiency. This article focuses on the GH gene, the various gene alterations, and their possible impact on the pituitary gland. Transcription factors regulating pituitary gland development may cause multiple pituitary hormone deficiency but may present initially as GH deficiency. The role of two most important transcription factors, POU1F1 (Pit-1) and PROP 1, is discussed. https://sonar.ch/global/documents/138438 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ecl.2006.11.010 info:eu-repo/semantics/altIdentifier/pmid/17336732 Endocrinology and metabolism clinics of North America. - 2007 Animals Dwarfism, Pituitary Growth Hormone Humans Mice Mice, Transgenic Mutation Pituitary Gland RNA Splice Sites Secretory Vesicles Transcription Factors Genetics of growth hormone deficiency. http://purl.org/coar/resource_type/c_6501