<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Kieffer N</dc:creator>
  <dc:creator>Nordmann P</dc:creator>
  <dc:creator>Moreno AM</dc:creator>
  <dc:creator>Zanolli Moreno L</dc:creator>
  <dc:creator>Chaby R</dc:creator>
  <dc:creator>Breton A</dc:creator>
  <dc:creator>Tissières P</dc:creator>
  <dc:creator>Poirel L</dc:creator>
  <dc:date>2018</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">A collection of 126 pigs was screened for carriage of colistin-resistant Enterobacteriaceae in a farm in Minas Gerais, Brazil. Out of this collection, eight colistin-resistant Escherichia coli isolates were recovered, including one from Minas Gerais State producing a new MCR-3 variant (MCR-3.12). Analysis of the lipopolysaccharide revealed that MCR-3.12 had a function similar to that of MCR-1 and MCR-2 as a result of the addition of a phosphoethanolamine group to the lipid A moiety. Genetic analysis showed that the mcr-3.12 gene was carried by an IncA/C2 plasmid and was embedded in an original genetic environment. This study reports the occurrence of the MCR-3-like determinant in South America and is the first to demonstrate the functionality of this group of enzymes as a phosphoethanolamine transferase.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/139012</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00278-18</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/29712655</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Antimicrobial agents and chemotherapy. - 2018</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">MCR-3</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">mcr</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">plasmid</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">polymyxins</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">swine</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Anti-Bacterial Agents</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Brazil</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Colistin</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Escherichia coli</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Escherichia coli Proteins</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Genetic Variation</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Genome, Bacterial</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Microbial Sensitivity Tests</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Plasmids</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Swine</dc:subject>
  <dc:subject xmlns:ns17="xml" ns17:lang="en">Transferases (Other Substituted Phosphate Groups)</dc:subject>
  <dc:title xmlns:ns18="xml" ns18:lang="en">Genetic and Functional Characterization of an MCR-3-Like Enzyme-Producing Escherichia coli Isolate Recovered from Swine in Brazil.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>