<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Entenza JM</dc:creator>
  <dc:creator>Loeffler JM</dc:creator>
  <dc:creator>Grandgirard D</dc:creator>
  <dc:creator>Fischetti VA</dc:creator>
  <dc:creator>Moreillon P</dc:creator>
  <dc:date>2005</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (&gt;4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/139337</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.49.11.4789-4792.2005</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/16251333</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Antimicrobial agents and chemotherapy. - 2005</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Cytokines</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Endocarditis, Bacterial</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Enzyme Therapy</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Enzymes</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Pneumococcal Infections</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Rats</dc:subject>
  <dc:title xmlns:ns8="xml" ns8:lang="en">Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>