Palazzesi F Prakash MK Bonomi M Barducci A 2015 Molecular Dynamics (MD) plays a fundamental role in characterizing protein disordered states that are emerging as crucial actors in many biological processes. Here we assess the accuracy of three current force-fields in modeling disordered peptides by combining enhanced-sampling MD simulations with NMR data. These force-fields generate significantly different conformational ensembles, and AMBER03w [ Best and Mittal J. Phys. Chem. B 2010 , 114 , 14916 - 14923 ] provides the best agreement with experiments, which is further improved by adding the ILDN corrections [ Lindorff-Larsen et al. Proteins 2010 , 78 , 1950 - 1958 ]. https://sonar.ch/global/documents/139775 eng info:eu-repo/semantics/altIdentifier/doi/10.1021/ct500718s info:eu-repo/semantics/altIdentifier/pmid/26574197 Journal of chemical theory and computation. - 2015 Molecular Dynamics Simulation Nuclear Magnetic Resonance, Biomolecular Protein Conformation Proteins Accuracy of current all-atom force-fields in modeling protein disordered states. http://purl.org/coar/resource_type/c_6501