Franzen D Butsch R Chaloupka K 2013 A 31-year-old man was referred with sudden onset of a painful periorbital angio-oedema. Assuming a first episode of allergic or acquired angio-oedema, the patient was treated with a plasma-derived C1 esterase inhibitor, tranexamic acid and fresh-frozen plasma, after the initial treatment with corticosteroids and histamine blockers was unsuccessful. As blood cultures grew group A streptococci, the diagnosis of periorbital necrotising fasciitis was made, and treatment was subsequently changed to clindamycin and ceftriaxone. Necrotising fasciitis involving the periorbita is a rare and potentially lethal differential diagnosis of acute angio-oedema, in particular if accompanied by severe pain and/or fever. Knowledge on the appearance of this disorder cannot be overemphasised, as only early recognition and immediate initiation of high-dose penicillin and clindamycin combined with tissue debridement help to decrease the mortality and morbidity. application/pdf https://sonar.ch/global/documents/141626 eng info:eu-repo/semantics/altIdentifier/doi/10.1136/bcr-2013-009315 info:eu-repo/semantics/altIdentifier/pmid/23697450 info:eu-repo/semantics/openAccess BMJ case reports. - 2013 Adult Angioedema Diagnosis, Differential Fasciitis, Necrotizing Humans Male Orbital Diseases Streptococcal Infections Streptococcus pyogenes Appearances are deceptive... http://purl.org/coar/resource_type/c_6501