Hottiger MO 2011 ADP-ribosylation is a covalent post-translational protein modification catalyzed by ADP-ribosyltransferases and is involved in important processes such as cell cycle regulation, DNA damage response, replication or transcription. Histones are ADP-ribosylated by ADP-ribosyltransferase diphtheria toxin-like 1 at specific amino acid residues, in particular lysines, of the histones tails. Specific ADP-ribosyl hydrolases and poly-ADP-ribose glucohydrolases degrade the ADP-ribose polymers. The ADP-ribose modification is read by zinc finger motifs or macrodomains, which then regulate chromatin structure and transcription. Thus, histone ADP-ribosylation may be considered an additional component of the histone code. application/pdf https://sonar.ch/global/documents/141765 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.febslet.2011.03.031 info:eu-repo/semantics/altIdentifier/pmid/21420964 info:eu-repo/semantics/openAccess FEBS letters. - 2011 Adenosine Diphosphate Animals Histone Code Histones Humans Poly(ADP-ribose) Polymerases Protein Processing, Post-Translational Ribose ADP-ribosylation of histones by ARTD1: an additional module of the histone code? http://purl.org/coar/resource_type/c_6501