Dincer C Bruch R Kling A Dittrich PS Urban GA 2017 Multiplexed point-of-care testing (xPOCT), which is simultaneous on-site detection of different analytes from a single specimen, has recently gained increasing importance for clinical diagnostics, with emerging applications in resource-limited settings (such as in the developing world, in doctors' offices, or directly at home). Nevertheless, only single-analyte approaches are typically considered as the major paradigm in many reviews of point-of-care testing. Here, we comprehensively review the present diagnostic systems and techniques for xPOCT applications. Different multiplexing technologies (e.g., bead- or array-based systems) are considered along with their detection methods (e.g., electrochemical or optical). We also address the unmet needs and challenges of xPOCT. Finally, we critically summarize the in-field applicability and the future perspectives of the presented approaches. application/pdf https://sonar.ch/global/documents/143680 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tibtech.2017.03.013 info:eu-repo/semantics/altIdentifier/pmid/28456344 info:eu-repo/semantics/openAccess Trends in biotechnology. - 2017 lab-on-a-chip (LOC) microfluidics multianalyte analysis multiplexing on-site testing point-of-care testing (POCT) Animals Humans Lab-On-A-Chip Devices Microfluidic Analytical Techniques Point-of-Care Systems Multiplexed Point-of-Care Testing - xPOCT. http://purl.org/coar/resource_type/c_6501