<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Hynes NE</dc:creator>
  <dc:creator>Lane HA</dc:creator>
  <dc:date>2005</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression. Accordingly, these receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ERBB inhibitors are now used in the clinic. We will discuss the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/15172</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1038/nrc1609</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/15864276</dc:relation>
  <dc:source>Nature reviews. Cancer. - 2005</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Antibodies, Monoclonal</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Antineoplastic Agents</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Antineoplastic Combined Chemotherapy Protocols</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Drug Delivery Systems</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Drug Resistance, Neoplasm</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Neoplasms</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Receptor Protein-Tyrosine Kinases</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Receptor, ErbB-2</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Signal Transduction</dc:subject>
  <dc:title xmlns:ns12="xml" ns12:lang="en">ERBB receptors and cancer: the complexity of targeted inhibitors.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>