De Libero G Mori L 2005 Recent studies have shown that the recognition of lipid antigens by the immune system is important for defence against infection and other diseases, and that lipid-specific responses occur at higher frequencies than previously suspected. Thanks to several recent advances in this field, we now have a better appreciation of the molecular and cellular requirements of T-cell stimulation by lipids. These findings have raised new questions about the mechanisms of lipid presentation, the priming and clonal expansion of lipid-specific T cells, and their differentiation into memory cells. A greater understanding of lipid-specific T cells and the molecular mechanisms of lipid immunogenicity should facilitate the development of lipid-based vaccines. https://sonar.ch/global/documents/15185 eng info:eu-repo/semantics/altIdentifier/doi/10.1038/nri1631 info:eu-repo/semantics/altIdentifier/pmid/15928680 Nature reviews. Immunology. - 2005 Animals Antigen-Presenting Cells Antigens, Bacterial Antigens, CD1 Autoantigens Autoimmunity Biological Transport Humans Immunologic Memory Lipid Metabolism Lipids Lymphopoiesis T-Lymphocytes Recognition of lipid antigens by T cells. http://purl.org/coar/resource_type/c_6501