Zbinden G Wunderli-Allenspach H Grimm L 1989 The effects of liposomes with positive, neutral and negative surface charges on platelets and the plasmatic coagulation system were investigated in several in vitro and in vivo models. Negatively charged liposomes stimulated the plasmatic contact activating system as demonstrated by significant acceleration of whole blood clotting time measured in containers with nonwettable (siliconized) surface. The same liposomes induced reversible aggregates of human platelets in vitro and circulating reversible platelet aggregates after intravenous infusion in guinea pigs. Liposomes with positive and neutral surface charges had no effect on plasmatic coagulation and platelets. The biological mechanisms and the toxicological relevance of these findings are discussed. https://sonar.ch/global/documents/152291 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/0300-483x(89)90063-2 info:eu-repo/semantics/altIdentifier/pmid/2705196 Toxicology. - 1989 Animals Blood Coagulation Cell Adhesion Electrochemistry Guinea Pigs Humans In Vitro Techniques Infusions, Intravenous Liposomes Platelet Aggregation Platelet Count Surface Properties Whole Blood Coagulation Time Assessment of thrombogenic potential of liposomes. http://purl.org/coar/resource_type/c_6501