Metanis N Hilvert D 2014 Once considered highly toxic, the element selenium is now recognized as a micronutrient essential for human health. It is inserted co-translationally into many proteins as the non-canonical amino acid selenocysteine, providing the resulting selenoprotein molecules with a range of valuable redox properties; selenocysteine is also increasingly exploited as a structural and mechanistic probe in synthetic peptides and proteins. Here we review topical investigations into the preparation and characterization of natural and artificial selenoproteins. Such molecules are uniquely suited as tools for protein chemistry and as a test bed for studying novel catalytic activities. https://sonar.ch/global/documents/153442 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cbpa.2014.09.010 info:eu-repo/semantics/altIdentifier/pmid/25261915 Current opinion in chemical biology. - 2014 Animals Humans Oxidation-Reduction Protein Biosynthesis Protein Folding Recombinant Proteins Selenocysteine Selenoproteins Natural and synthetic selenoproteins. http://purl.org/coar/resource_type/c_6501