Markkanen E van Loon B Ferrari E Hübscher U 2011 DNA polymerase (pol) λ, one of the 15 cellular pols, belongs to the X family. It is a small 575 amino-acid protein containing a polymerase, a dRP-lyase, a proline/serine rich and a BRCT domain. Pol λ shows various enzymatic activities including DNA polymerization, terminal transferase and dRP-lyase. It has been implicated to play a role in several DNA repair pathways, particularly base excision repair (BER), non-homologous end-joining (NHEJ) and translesion DNA synthesis (TLS). Similarly to other DNA repair enzymes, pol λ undergoes posttranslational modifications during the cell cycle that regulate its stability and possibly its subcellular localization. Here we describe our knowledge about ubiquitylation of pol λ and the impact of this modification on its regulation. https://sonar.ch/global/documents/165763 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.febslet.2011.03.069 info:eu-repo/semantics/altIdentifier/pmid/21486570 FEBS letters. - 2011 Binding Sites DNA DNA Damage DNA Ligase ATP DNA Ligases DNA Polymerase beta DNA Repair DNA Replication DNA-Binding Proteins Humans Ubiquitination Ubiquitylation of DNA polymerase λ. http://purl.org/coar/resource_type/c_6501