Piemontesi C Wang Q Zhu J 2016 A gram-scale enantioselective total synthesis of (+)-peganumine A was accomplished in 7 steps from commercially available 6-methoxytryptamine. Key steps included (a) a Liebeskind-Srogl cross-coupling; (b) a one-pot construction of the tetracyclic skeleton from an ω-isocyano-γ-oxo-aldehyde via a sequence of an unprecedented C-C bond forming lactamization and a transannular condensation; (c) a one-pot organocatalytic process merging two achiral building blocks into an octacyclic structure via a sequence of enantioselective Pictet-Spengler reaction followed by a transannular cyclization. This last reaction created two spirocycles and a 2,7-diazabicyclo[2.2.1]heptan-3-one unit with excellent control of both the absolute and relative stereochemistry of the two newly created quaternary stereocenters. https://sonar.ch/global/documents/166438 eng info:eu-repo/semantics/altIdentifier/doi/10.1021/jacs.6b07846 info:eu-repo/semantics/altIdentifier/pmid/27558528 Journal of the American Chemical Society. - 2016 Carbolines Carboxylic Acids Catalysis Chemistry Techniques, Synthetic Stereoisomerism Enantioselective Synthesis of (+)-Peganumine A. http://purl.org/coar/resource_type/c_6501