Baumann CR Stocker R Imhof HG Trentz O Hersberger M Mignot E Bassetti CL 2005 Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders. https://sonar.ch/global/documents/16698 eng info:eu-repo/semantics/altIdentifier/doi/10.1212/01.wnl.0000167605.02541.f2 info:eu-repo/semantics/altIdentifier/pmid/16009905 Neurology. - 2005 Adolescent Adult Aged Autonomic Nervous System Body Temperature Brain Injuries Female Humans Hypothalamic Area, Lateral Hypothalamic Diseases Hypothalamus Hypothalamus, Posterior Intracellular Signaling Peptides and Proteins Male Middle Aged Neural Pathways Neuropeptides Orexins Prospective Studies Sleep Sleep Wake Disorders Wakefulness Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury. http://purl.org/coar/resource_type/c_6501