Jung JY Ried MK Hothorn M Poirier Y 2018 Proteins containing a SPX domain are involved in phosphate (Pi) homeostasis, including Pi transport and adaptation to Pi deficiency. The SPX domain harbors a basic surface binding Pi at low affinity and inositol pyrophosphates (PP-InsPs) at high affinity. Genetic and biochemical studies revealed that PP-InsPs serve as ligands for the SPX domain. Residues in the PHO1 SPX domain involved in PP-InsPs binding are critical for its Pi export activity, and the interaction between SPX proteins and the PHR1 transcription factor, which results in PHR1 inactivation, is promoted by PP-InsPs. Changes in PP-InsPs levels in response to Pi deficiency may thus contribute to the adaptation of plants to stress via the modulation of the activity of SPX-containing proteins and their interactors. Modulating PP-InsP levels or the affinity/specificity of the SPX domain for PP-InsP could potentially be used to engineer crops to maintain high yield under reduced Pi fertilizer input. application/pdf https://sonar.ch/global/documents/169286 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.copbio.2017.08.012 info:eu-repo/semantics/altIdentifier/pmid/28889038 info:eu-repo/semantics/openAccess Current opinion in biotechnology. - 2018 Biological Transport Homeostasis Inositol Phosphates Phosphates Plants Transcription Factors Control of plant phosphate homeostasis by inositol pyrophosphates and the SPX domain. http://purl.org/coar/resource_type/c_6501