<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Okamoto Y</dc:creator>
  <dc:creator>Ward TR</dc:creator>
  <dc:date>2017</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Cross-regulation of complex biochemical reaction networks is an essential feature of living systems. In a biomimetic spirit, we report on our efforts to program the temporal activation of an artificial metalloenzyme via cross-regulation by a natural enzyme. In the presence of urea, urease slowly releases ammonia that reversibly inhibits an artificial transfer hydrogenase. Addition of an acid, which acts as fuel, allows to maintain the system out of equilibrium.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/173971</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1002/anie.201702181</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/28485105</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Angewandte Chemie (International ed. in English). - 2017</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">artificial metalloenzymes</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">biocatalysis</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">cross-regulation</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">hydrogenation</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">urease</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Ammonia</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Biocatalysis</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Biomimetics</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Canavalia</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Enrofloxacin</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Hydrogen-Ion Concentration</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Hydrogenase</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Metalloproteins</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Urea</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Urease</dc:subject>
  <dc:title xmlns:ns16="xml" ns16:lang="en">Cross-Regulation of an Artificial Metalloenzyme.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>