Gradilla, Ana-Citlali Simon, Eléanor Aguilar, Gustavo Guerrero, Isabel 2018 <jats:p>Signalling from cell-to-cell is fundamental for determining differentiation and patterning. This communication can occur between adjacent and distant cells. Extracellular vesicles (EVs) are membrane-based structures thought to facilitate the long-distance movement of signalling molecules. EVs have recently been found to allow the transport of two major developmental signalling pathways: Hedgehog and Wnt. These signalling molecules undergo crucial post-translational lipid modifications, which anchor them to membranes and impede their free release into the extracellular space. Preparation of these ligands in EVs involves intracellular vesicle sorting in an endocytosis-dependent recycling process before secretion. In the present review, we discuss the most recent advances with regard to EV involvement in developmental signalling at a distance. We focus on the role of the protein complexes involved in EV genesis, and provide a comprehensive perspective of the contribution of these complexes to intracellular vesicle sorting of developmental signals for their extracellular secretion, reception and transduction.</jats:p> https://sonar.ch/global/documents/174154 eng info:eu-repo/semantics/altIdentifier/doi/10.1042/ebc20180001 info:eu-repo/semantics/altIdentifier/issn/0071-1365 Essays in Biochemistry. - Portland Press Ltd.. - 2018, vol. 62, no. 2, p. 215-223 Biochemistry Molecular Biology From intra- to extracellular vesicles: extracellular vesicles in developmental signalling http://purl.org/coar/resource_type/c_6501