Gummalla M Maeda RK Castro Alvarez JJ Gyurkovics H Singari S Edwards KA Karch F Bender W 2012 The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qualified in the case of abdominal-A (abd-A) repression by Abdominal-B (Abd-B). Animals lacking Abd-B show ectopic expression of abd-A in the epidermis of the eighth abdominal segment, but not in the central nervous system. Repression in these neuronal cells is accomplished by a 92 kb noncoding RNA. This "iab-8 RNA" produces a micro RNA to repress abd-A, but also has a second, redundant repression mechanism that acts only "in cis." Transcriptional interference with the abd-A promoter is the most likely mechanism. application/pdf https://sonar.ch/global/documents/174600 eng info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.1002720 info:eu-repo/semantics/altIdentifier/pmid/22654672 info:eu-repo/semantics/openAccess PLoS genetics. - 2012 Abdomen Animals Base Sequence Drosophila Drosophila Proteins Embryonic Development Gene Expression Regulation, Developmental Homeodomain Proteins Infertility MicroRNAs Molecular Sequence Data Morphogenesis Mutation Neurons Nuclear Proteins Promoter Regions, Genetic RNA, Untranslated Transcription Factors abd-A regulation by the iab-8 noncoding RNA. http://purl.org/coar/resource_type/c_6501