<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Cherkaoui S</dc:creator>
  <dc:creator>Mateus L</dc:creator>
  <dc:creator>Christen P</dc:creator>
  <dc:creator>Veuthey JL</dc:creator>
  <dc:date>1998</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The simultaneous determination of atropine and scopolamine derivatives, which have similar structures, was investigated by using capillary zone electrophoresis. The effects of buffer pH, buffer concentration and hydroxypropyl-beta-cyclodextrin concentration on migration time and resolution of the investigated compounds were systematically studied. The selected electrophoretic buffer consisted of a 80 mM sodium citrate pH 2.5, containing 2.5 mM hydroxypropyl-beta-cyclodextrin as the complexing agent. Quantitative analysis was validated by testing the reproducibility of the method, giving a relative standard deviation less than 1 and 2% for the intermediate precision of migration times and peak area ratios, respectively. The linearity of the method was assessed between 50 and 150% of the theoretical content (coefficient of correlation greater than 0.99). The proposed method was found to be suitable and accurate for the determination of these basic drugs in pharmaceutical preparations.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/175095</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/s0731-7085(98)00083-1</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/9884207</dc:relation>
  <dc:source>Journal of pharmaceutical and biomedical analysis. - 1998</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">2-Hydroxypropyl-beta-cyclodextrin</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Atropine Derivatives</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Cyclodextrins</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Drug Contamination</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Electrophoresis, Capillary</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Hydrogen-Ion Concentration</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Reproducibility of Results</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Scopolamine Derivatives</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Sensitivity and Specificity</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Time Factors</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">beta-Cyclodextrins</dc:subject>
  <dc:title xmlns:ns12="xml" ns12:lang="en">Validated capillary electrophoresis method for the determination of atropine and scopolamine derivatives in pharmaceutical formulations.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>