Deppe H Mücke T Wagenpfeil S Kesting M Rozej A Bajbouj M Sculean A 2015 BACKGROUND The purpose of this clinical study was to assess the prevalence of acidic oral mucosal lesions and periodontal conditions in patients suffering from erosive esophageal reflux disease (ERD) compared with non erosive esophageal reflux disease (NERD) patients, both treated with long term proton pump inhibitors (PPI). METHODS Seventy-one patients with diagnosed GERD were studied: i.e. 29 ERD and 42 NERD patients. Thorough visual examination of the oral mucosa and a periodontal evaluation was performed. The primary outcome was defined as a statistically significant difference, between the two groups, in the presence of acidic lesions of the oral mucosa and specific periodontal parameters. RESULTS This study failed to demonstrate statistically significant differences between ERD and NERD patients with respect to the prevalence of oral mucosal lesions. However, significantly more ERD patients suffered from severe periodontitis (CAL ≥ 5 mm) as compared to NERD patients. Accordingly, it may be assumed that PPI-use had no adverse effects on the prevalence of acidic oral mucosal lesions and on periodontal destruction. CONCLUSIONS Within the limitations of this study it may be concluded that ERD and NERD patients need separate evaluation with respect to periodontal destruction. Moreover, long term PPI medication had no adverse clinical impact on acidic oral mucosal lesions and periodontal destruction. Further studies are necessary to elucidate the role of reflux in the periodontal destruction of ERD individuals. https://sonar.ch/global/documents/177968 eng info:eu-repo/semantics/altIdentifier/doi/10.1186/s12903-015-0069-8 info:eu-repo/semantics/altIdentifier/pmid/26208714 BMC oral health. - 2015 Adult Aged Aged, 80 and over Anti-Ulcer Agents Dental Plaque Index Erythema Female Gastric Acid Gastroesophageal Reflux Humans Male Middle Aged Mouth Diseases Oral Ulcer Periodontal Attachment Loss Periodontal Diseases Periodontal Index Periodontal Pocket Periodontitis Photography, Dental Proton Pump Inhibitors Stomatitis Tongue Diseases Young Adult Erosive esophageal reflux vs. non erosive esophageal reflux: oral findings in 71 patients. http://purl.org/coar/resource_type/c_6501