<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Dummer R</dc:creator>
  <dc:creator>Willers J</dc:creator>
  <dc:creator>Kamarashev J</dc:creator>
  <dc:creator>Urosevic M</dc:creator>
  <dc:creator>Döbbeling U</dc:creator>
  <dc:creator>Burg G</dc:creator>
  <dc:date>2000</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Cutaneous lymphomas are a heterogeneous group of lymphoproliferative disorders derived from T cells, B cells and, in rare cases, natural killer cells. The precise mechanisms of the lymphomagenesis are still obscure. However, there are various factors involved. These factors include environmental, especially infectious factors, translocations, mutations and genetic instability. The special microenvironment in the skin is responsible for the peculiar behavior of these neoplasms by providing various key factors, such as adhesion molecules and cytokines. Newly identified molecular disturbances in cutaneous lymphomas might be targeted by specific molecular or immunologic interventions in the future.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/179276</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/s1085-5629(00)80003-6</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/10892708</dc:relation>
  <dc:source>Seminars in cutaneous medicine and surgery. - 2000</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Cell Transformation, Neoplastic</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Cytokines</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Cytopathogenic Effect, Viral</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Deltaretrovirus</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Environmental Exposure</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Herpesvirus 4, Human</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Lymphoma, B-Cell</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Lymphoma, T-Cell, Cutaneous</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Mutation</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Skin Neoplasms</dc:subject>
  <dc:title xmlns:ns12="xml" ns12:lang="en">Pathogenesis of cutaneous lymphomas.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>