<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>van der Goot G</dc:creator>
  <dc:creator>Young JA</dc:creator>
  <dc:date>2009</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cellular receptors, and how receptor-type can dictate the low pH threshold of PA pore formation. The roles played by cellular factors in regulating the endocytosis of toxin-receptor complexes is also discussed.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/180371</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mam.2009.08.007</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/19732789</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Molecular aspects of medicine. - 2009</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Adaptor Proteins, Signal Transducing</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Antigens, Bacterial</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Bacillus anthracis</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Bacterial Toxins</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Endocytosis</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Endosomes</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">GTPase-Activating Proteins</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Hydrogen-Ion Concentration</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Low Density Lipoprotein Receptor-Related Protein-6</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Models, Molecular</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Protein Conformation</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Protein Subunits</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Receptors, LDL</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Receptors, Peptide</dc:subject>
  <dc:title xmlns:ns17="xml" ns17:lang="en">Receptors of anthrax toxin and cell entry.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>