Chopard B Borgdorff J Hoekstra AG 2014 We review a methodology to design, implement and execute multi-scale and multi-science numerical simulations. We identify important ingredients of multi-scale modelling and give a precise definition of them. Our framework assumes that a multi-scale model can be formulated in terms of a collection of coupled single-scale submodels. With concepts such as the scale separation map, the generic submodel execution loop (SEL) and the coupling templates, one can define a multi-scale modelling language which is a bridge between the application design and the computer implementation. Our approach has been successfully applied to an increasing number of applications from different fields of science and technology. application/pdf https://sonar.ch/global/documents/182541 eng info:eu-repo/semantics/altIdentifier/doi/10.1098/rsta.2013.0378 info:eu-repo/semantics/altIdentifier/pmid/24982249 info:eu-repo/semantics/openAccess Philosophical transactions. Series A, Mathematical, physical, and engineering sciences. - 2014 framework methodology modelling multi-scale multi-scale parallelism simulation A framework for multi-scale modelling. http://purl.org/coar/resource_type/c_6501