<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Nickel, Thomas</dc:creator>
  <dc:creator>Hanssen, Henner</dc:creator>
  <dc:creator>Emslander, Ingrid</dc:creator>
  <dc:creator>Drexel, Verena</dc:creator>
  <dc:creator>Hertel, Gernot</dc:creator>
  <dc:creator>Schmidt-Trucksäss, Arno</dc:creator>
  <dc:creator>Summo, Claudia</dc:creator>
  <dc:creator>Sisic, Zeljka</dc:creator>
  <dc:creator>Lambert, Marius</dc:creator>
  <dc:creator>Hoster, Eva</dc:creator>
  <dc:creator>Halle, Martin</dc:creator>
  <dc:creator>Weis, Michael</dc:creator>
  <dc:description xmlns:ns0="xml" ns0:lang="en">&lt;jats:p&gt;&lt;jats:italic&gt;Introduction&lt;/jats:italic&gt;. Physical inactivity and obesity are independent risk factors for atherosclerosis. We analyzed the immunomodulatory capacity of 10-week intensified exercise training (ET) in obese and lean athletes. Markers of the innate immune response were investigated in obese (ONE: ET≤40 km/week) and lean athletes (LNE: ET≤40 km/week and LE: ET≥55 km/week).&lt;jats:italic&gt;Methods&lt;/jats:italic&gt;. Circulating dendritic cells (DC) were analyzed by flow-cytometry for BDCA-1/-2-expression. TLR-2/-4/-7 and MyD88 were analyzed by RT-PCR and Western blot. Circulating oxLDL levels were analyzed by ELISA.&lt;jats:italic&gt;Results&lt;/jats:italic&gt;. BDCA-1 expression at baseline was lower in ONE compared to both other groups (ONE 0.15%; LNE 0.27%; LE 0.33%; ), but significantly increased in ONE after training (+50%; ). In contrast, BDCA-2 expression at baseline was higher in ONE (ONE 0.25%; LNE 0.11%; LE 0.09%; ) and decreased in ONE after the 10-week training period (−27%; ). Gene activations of TLR-4 and TLR-7 with corresponding protein increase were found for all three groups (/) compared to pre training. A reduction of oxLDL levels was seen in ONE (−61%; ).&lt;jats:italic&gt;Conclusions&lt;/jats:italic&gt;. Intensified exercise induces an increase of BDCA-1+ DCs and TLR-4/-7 in obese athletes. We hereby describe new immune modulatory effects, which—through regular aerobic exercise—modulate innate immunity and pro-inflammatory cytokines in obesity.&lt;/jats:p&gt;</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/183560</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1155/2011/308965</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/issn/0962-9351</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Mediators of Inflammation. - Hindawi Limited. - 2011, vol. 2011, p. 1-10</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Immunology</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Cell Biology</dc:subject>
  <dc:title xmlns:ns3="xml" ns3:lang="en">Immunomodulatory Effects of Aerobic Training in Obesity</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>