Rothballer A Schwartz TU Kutay U 2013 Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the double membrane of the nuclear envelope (NE) and physically connect nuclear structures to cytoskeletal elements. LINC complexes are envisioned as force transducers in the NE, which facilitate processes like nuclear anchorage and migration, or chromosome movements. The complexes are built from members of two evolutionary conserved families of transmembrane (TM) proteins, the SUN (Sad1/UNC-84) domain proteins in the inner nuclear membrane (INM) and the KASH (Klarsicht/ANC-1/SYNE homology) domain proteins in the outer nuclear membrane (ONM). In the lumen of the NE, the SUN and KASH domains engage in an intimate assembly to jointly form a NE bridge. Detailed insights into the molecular architecture and atomic structure of LINC complexes have recently revealed the molecular basis of nucleo-cytoskeletal coupling. They bear important implications for LINC complex function and suggest new potential and as yet unexplored roles, which the complexes may play in the cell. application/pdf https://sonar.ch/global/documents/183945 eng info:eu-repo/semantics/altIdentifier/doi/10.4161/nucl.23387 info:eu-repo/semantics/altIdentifier/pmid/23324460 info:eu-repo/semantics/openAccess Nucleus (Austin, Tex.). - 2013 KASH domain LINC complex SUN domain mechanotransduction membrane fusion nuclear envelope nuclear membrane spacing nuclear pore complex spermatogenesis spindle pole body Cytoskeleton Humans Intracellular Signaling Peptides and Proteins Mechanotransduction, Cellular Membrane Proteins Microtubule-Associated Proteins Nuclear Envelope Nuclear Matrix Nuclear Proteins Protein Structure, Tertiary Protein-Serine-Threonine Kinases LINCing complex functions at the nuclear envelope: what the molecular architecture of the LINC complex can reveal about its function. http://purl.org/coar/resource_type/c_6501