<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Ebert D</dc:creator>
  <dc:date>1998</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Serial passage experiments are a form of experimental evolution that is frequently used in applied sciences; for example, in vaccine development. During these experiments, molecular and phenotypic evolution can be monitored in real time, providing insights into the causes and consequences of parasite evolution. Within-host competition generally drives an increase in a parasite's virulence in a new host, whereas the parasite becomes avirulent to its former host, indicating a trade-off between parasite fitnesses on different hosts. Understanding why parasite virulence seldom escalates similarly in natural populations could help us to manage virulence and deal with emerging diseases.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/184282</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1126/science.282.5393.1432</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/9822369</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Science (New York, N.Y.). - 1998</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Adaptation, Physiological</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Bacteria</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Biological Evolution</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Fungi</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Genetic Variation</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Host-Parasite Interactions</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Mutation</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Parasites</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Serial Passage</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Virulence</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Viruses</dc:subject>
  <dc:title xmlns:ns13="xml" ns13:lang="en">Experimental evolution of parasites.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>