Bally L Kempf P Zueger T Speck C Pasi N Ciller C Feller K Loher H Rosset R Wilhelm M Boesch C Buehler T Dokumaci AS Tappy L Stettler C 2017 This paper aims to compare the metabolic effects of glucose-fructose co-ingestion (GLUFRU) with glucose alone (GLU) in exercising individuals with type 1 diabetes mellitus. Fifteen male individuals with type 1 diabetes (HbA1c 7.0% ± 0.6% (53 ± 7 mmol/mol)) underwent a 90 min iso-energetic continuous cycling session at 50% VO2max while ingesting combined glucose-fructose (GLUFRU) or glucose alone (GLU) to maintain stable glycaemia without insulin adjustment. GLUFRU and GLU were labelled with 13C-fructose and 13C-glucose, respectively. Metabolic assessments included measurements of hormones and metabolites, substrate oxidation, and stable isotopes. Exogenous carbohydrate requirements to maintain stable glycaemia were comparable between GLUFRU and GLU (p = 0.46). Fat oxidation was significantly higher (5.2 ± 0.2 vs. 2.6 ± 1.2 mg·kg-1·min-1, p < 0.001) and carbohydrate oxidation lower (18.1 ± 0.8 vs. 24.5 ± 0.8 mg·kg-1·min-1p < 0.001) in GLUFRU compared to GLU, with decreased muscle glycogen oxidation in GLUFRU (10.2 ± 0.9 vs. 17.5 ± 1.0 mg·kg-1·min-1, p < 0.001). Lactate levels were higher (2.2 ± 0.2 vs. 1.8 ± 0.1 mmol/L, p = 0.012) in GLUFRU, with comparable counter-regulatory hormones between GLUFRU and GLU (p > 0.05 for all). Glucose and insulin levels, and total glucose appearance and disappearance were comparable between interventions. Glucose-fructose co-ingestion may have a beneficial impact on fuel metabolism in exercising individuals with type 1 diabetes without insulin adjustment, by increasing fat oxidation whilst sparing glycogen. application/pdf https://sonar.ch/global/documents/185133 eng info:eu-repo/semantics/altIdentifier/doi/10.3390/nu9020164 info:eu-repo/semantics/altIdentifier/pmid/28230765 info:eu-repo/semantics/openAccess Nutrients. - 2017 carbohydrates exercise fructose glucose glycaemia substrate oxidation type 1 diabetes Adult Bicycling Blood Glucose Diabetes Mellitus, Type 1 Diet Dietary Carbohydrates Dietary Fats Eating Exercise Fructose Glucose Glycogen Hormones Humans Insulin Lactic Acid Male Muscles Oxygen Consumption Sports Nutritional Physiological Phenomena Young Adult Metabolic Effects of Glucose-Fructose Co-Ingestion Compared to Glucose Alone during Exercise in Type 1 Diabetes. http://purl.org/coar/resource_type/c_6501