Wieser M Buetler L Koenig A Riener R 2010 Clinical scales represent the golden standard in characterizing awareness for patients in vegetative or in a minimally conscious state. Clinical scales suffer from problems of sensitivity, specificity, subjectivity, and inter-rater reliability. This leads to a misdiagnosis rate of up to 40% and consequences associated with inappropriate treatment decisions. In this study, objective measures including physiological and neurological signals are used to quantify the patient status. Using linear backward regression analysis, 13 variables (based on frequency analysis of the electrocardiogram, heart rate variability, amplitude and latency of the P300, skin conductance responses, changes in the blood pressure and respiration signal) were found to be sufficient to describe 74.7% of the variability of the scores. In this regression model, the P300, electrocardiogram and the blood pressure signal account for most of the variability. More patient data and additional measures will enable refinement of the methods. This new objective-measurement based model of the state of awareness will complement the clinical scales in order to increase the quality of diagnosis. application/pdf https://sonar.ch/global/documents/185229 eng info:eu-repo/semantics/altIdentifier/doi/10.1109/IEMBS.2010.5626763 info:eu-repo/semantics/altIdentifier/pmid/21096471 info:eu-repo/semantics/openAccess Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. - 2010 Adult Awareness Female Glasgow Coma Scale Humans Male Middle Aged Persistent Vegetative State Young Adult Quantitative description of the state of awareness of patients in vegetative and minimally conscious state. http://purl.org/coar/resource_type/c_6501