<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Schmid C</dc:creator>
  <dc:creator>Schläpfer I</dc:creator>
  <dc:creator>Futo E</dc:creator>
  <dc:creator>Waldvogel M</dc:creator>
  <dc:creator>Schwander J</dc:creator>
  <dc:creator>Zapf J</dc:creator>
  <dc:creator>Froesch ER</dc:creator>
  <dc:date>1992</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Osteoblast-like cells prepared from neonatal rat calvariae and grown under serum-free conditions produce IGF-1 and IGFBPs. In contrast to growth hormone, T3 and PTH increased both IGF-1 mRNA expression and net IGF-1 release in calvaria cells. In addition, they stimulated net production of IGFBP-3 and of an IGFBP with an apparent molecular weight of 32 kDa which was recognized by an antiserum against rat IGFBP-2. Bone cells expressed remarkably high levels of mRNA for IGFBP-2, the predominant IGFBP in serum of newborn rats. T3 at low physiological concentrations but not growth hormone stimulated IGFBP-2 mRNA expression and IGFBP-2 production in bone cells in vitro. Thus, IGFBPs are differentially regulated by these hormones and may play an autocrine/paracrine regulatory role in bone.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/185369</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1530/acta.0.1260467</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/1377854</dc:relation>
  <dc:source>Acta endocrinologica. - 1992</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Carrier Proteins</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Growth Hormone</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Hypophysectomy</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Insulin-Like Growth Factor Binding Protein 2</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Insulin-Like Growth Factor I</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Molecular Weight</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Osteoblasts</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Parathyroid Hormone</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">RNA, Messenger</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Rats</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Somatomedins</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Triiodothyronine</dc:subject>
  <dc:title xmlns:ns14="xml" ns14:lang="en">Triiodothyronine (T3) stimulates insulin-like growth factor (IGF)-1 and IGF binding protein (IGFBP)-2 production by rat osteoblasts in vitro.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>