<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Schaller C</dc:creator>
  <dc:creator>Demange R</dc:creator>
  <dc:creator>Picasso S</dc:creator>
  <dc:creator>Vogel P</dc:creator>
  <dc:date>1999</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">(-)-(3aS,5S,6S.6aR)-3a,5,6,6a-Tetrahydro-5,6-isopropylide nedioxyfuro [2,3-d]isoxazole-3-methanol ((-)-5) has been tested toward 25 glycohydrolases and found to inhibit beta-galactosidase from Aspergillus niger (Ki = 18 microM) and that from Aspergillus orizae (Ki = 72 microM). Hydrolysis of the acetonide or exchange of CH2OH group for a CHO, CH2OMe or a CH2OMOM group suppresses the inhibitory activity.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/189439</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/s0960-894x(98)00722-7</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/10021944</dc:relation>
  <dc:source>Bioorganic &amp; medicinal chemistry letters. - 1999</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Aspergillus</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Dose-Response Relationship, Drug</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Furans</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Hydrogen-Ion Concentration</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Hydrolysis</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Inhibitory Concentration 50</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Isoxazoles</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Magnetic Resonance Spectroscopy</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">beta-Galactosidase</dc:subject>
  <dc:title xmlns:ns10="xml" ns10:lang="en">Specific, uncompetitive inhibition of beta-galactosidases by a 5,6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol derivative.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>
