<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Mpandi M</dc:creator>
  <dc:creator>Otten LA</dc:creator>
  <dc:creator>Lavanchy C</dc:creator>
  <dc:creator>Acha-Orbea H</dc:creator>
  <dc:creator>Finke D</dc:creator>
  <dc:date>2003</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Mouse mammary tumor virus (MMTV) infects the host via mucosal surfaces and exploits the host immune system for systemic spread and chronic infection. We have tested a neutralizing rat monoclonal antibody specific for the retroviral envelope glycoprotein gp52 for its efficiency in preventing acute and chronic mucosal and systemic infection. The antibody completely inhibits the superantigen response and chronic viral infection following systemic or nasal infection. Surprisingly however, the antibody only partially inhibits the early infection of antigen-presenting cells in the draining lymph node. Despite this initially inefficient protection from infection, superantigen-specific B- and T-cell responses and systemic viral spread are abolished, leading to complete clearance of the retroviral infection and hence interruption of the viral life cycle. In conclusion, systemic neutralizing monoclonal antibodies can provide an efficient protection against chronic retroviral amplification and persistence.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/189514</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1128/jvi.77.17.9369-9377.2003</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/12915552</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Journal of virology. - 2003</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Antibodies, Monoclonal</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Antibodies, Viral</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Antigens, Viral, Tumor</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">B-Lymphocytes</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Base Sequence</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Cell Differentiation</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">DNA, Viral</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Female</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Immunity, Mucosal</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Immunization, Passive</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Mammary Neoplasms, Experimental</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Mammary Tumor Virus, Mouse</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Mice</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Mice, Inbred BALB C</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Neutralization Tests</dc:subject>
  <dc:subject xmlns:ns17="xml" ns17:lang="en">Rats</dc:subject>
  <dc:subject xmlns:ns18="xml" ns18:lang="en">Rats, Inbred Lew</dc:subject>
  <dc:subject xmlns:ns19="xml" ns19:lang="en">Retroviridae Infections</dc:subject>
  <dc:subject xmlns:ns20="xml" ns20:lang="en">Tumor Virus Infections</dc:subject>
  <dc:title xmlns:ns21="xml" ns21:lang="en">Passive immunization with neutralizing antibodies interrupts the mouse mammary tumor virus life cycle.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>