<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Roviello G</dc:creator>
  <dc:creator>D'Angelo A</dc:creator>
  <dc:creator>Generali D</dc:creator>
  <dc:creator>Pittacolo M</dc:creator>
  <dc:creator>Ganzinelli M</dc:creator>
  <dc:creator>Iezzi G</dc:creator>
  <dc:creator>Manzini N</dc:creator>
  <dc:creator>Sobhani N</dc:creator>
  <dc:date>2019</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Gastric cancer (GC) is the fifth most common malignancy and the third cause of cancer-related deaths worldwide. Currently, surgery and chemotherapy remain the main therapeutic options and the prognosis of the disease is still poor in the metastatic setting. Avelumab is a human IgG1 antibody directed against PD-L1 approved for Merkel cell carcinoma and urothelial carcinoma that could be useful also for the treatment of GC. This review describes the chemical structure, the pharmacologic properties and the current knowledge of the efficacy of avelumab in the treatment of GC from the data available on the first and later phase clinical trials. The ongoing studies testing this drug either alone or in combination with other drugs are also described.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/195159</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.2217/imt-2019-0011</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/31060469</dc:relation>
  <dc:source>Immunotherapy. - 2019</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">avelumab</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">gastric cancer</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">immunotherapy</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Antibodies, Monoclonal</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">B7-H1 Antigen</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Carcinoma, Merkel Cell</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Carcinoma, Transitional Cell</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Clinical Trials as Topic</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Immunoglobulin G</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Skin Neoplasms</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Stomach Neoplasms</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Treatment Outcome</dc:subject>
  <dc:title xmlns:ns14="xml" ns14:lang="en">Avelumab in gastric cancer.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>