Stupp R Reni M Gatta G Mazza E Vecht C 2007 Anaplastic astrocytoma is an uncommon disease in the adult population. Prognosis is influenced by age, symptom duration, mental status and Karnofsky performance status. A truly complete resection, which is a recognized independent prognostic factor, is not possible and recurrence in the surgical cavity is common. Based on randomized data available, chemotherapy has consistently failed to improve the outcome of patients with anaplastic astrocytoma, while a meta-analysis showed a small, but significant improvement in survival favouring the use of chemotherapy. Outside a clinical trial, postoperative radiotherapy (30 x 2 Gy) remains the standard adjuvant therapy for most patients. For elderly patients, the application of treatment is usually based on performance status and neurological function. In recurrent disease, chemotherapy with temozolomide has been proven to be active and well-tolerated in phase II trials, but no comparative phase III trials of other cytotoxic drugs have been conducted. https://sonar.ch/global/documents/19947 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.critrevonc.2007.03.003 info:eu-repo/semantics/altIdentifier/pmid/17478095 Critical reviews in oncology/hematology. - 2007 Adolescent Adult Aged Antineoplastic Agents, Alkylating Astrocytoma Brain Neoplasms Clinical Trials as Topic Clinical Trials, Phase II as Topic Dacarbazine Female Humans Incidence Male Middle Aged Neoplasm Recurrence, Local Prognosis Risk Factors Survival Analysis Temozolomide Anaplastic astrocytoma in adults. http://purl.org/coar/resource_type/c_6501