<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Frei R</dc:creator>
  <dc:creator>Roduit C</dc:creator>
  <dc:creator>Ferstl R</dc:creator>
  <dc:creator>O'Mahony L</dc:creator>
  <dc:creator>Lauener RP</dc:creator>
  <dc:date>2019</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Rural lifestyle has been shown to be highly protective against the development of allergies. Contact to farm-animals or pets and early-life consumption of milk products turned out to be important. These exposures provide contact to N-glycolylneuraminic acid (Neu5Gc), a sialic acid naturally expressed in mammalians but not in humans or microbes although both are able to incorporate exogenously provided Neu5Gc and induce thereby an anti-Neu5Gc antibody response. Farmers' children had elevated levels of anti-Neu5Gc antibodies associated with increased contact to Neu5Gc. Farm-related exposures that were associated with protection against allergies such as exposure to farm-animals or pets and consumption of milk were also associated with an antibody response to Neu5Gc in children. Exposure to cats was associated with increased anit-Neu5Gc IgG levels at different timepoints assessed between 1 year of age and school-age. Moreover, consumption of non-pasteurized milk in the first year of life was associated with increased anti-Neu5Gc IgG levels. Neu5Gc-providing exposures that were associated with protection against allergies were reflected in an elevated anti-Neu5Gc IgG level in children. Exposure to Neu5Gc was associated with anti-inflammation and protection of asthma development in children and mice without contribution of anti-Neu5Gc antibodies.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/200999</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2019.01628</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/31379833</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Frontiers in immunology. - 2019</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">N-glycolylneuraminic acid</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">animal contact</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">anti-inflammatory</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">asthma</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">hygiene hypothesis</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">regulatory T cells</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Allergens</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Antibodies, Monoclonal</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Antibody Formation</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Asthma</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Cats</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Hypersensitivity</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Immunoglobulin G</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Inflammation</dc:subject>
  <dc:subject xmlns:ns17="xml" ns17:lang="en">Life Style</dc:subject>
  <dc:subject xmlns:ns18="xml" ns18:lang="en">Mice</dc:subject>
  <dc:subject xmlns:ns19="xml" ns19:lang="en">Neuraminic Acids</dc:subject>
  <dc:title xmlns:ns20="xml" ns20:lang="en">Exposure of Children to Rural Lifestyle Factors Associated With Protection Against Allergies Induces an Anti-Neu5Gc Antibody Response.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>